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´╗┐pen to produce more CRP throughout their lives and others who just happen to produce less. If CRP causes heart disease, those who make more would have more heart disease. That, however, is not what the study found. The association between CRP and heart disease must be reflecting something else. For example, if CRP levels go up when heart disease begins, because of inflammation in arteries, CRP levels would be higher in people with incipient heart disease. But CRP itself would be playing no role in heart disease risk; it was just marker of inflammation. A smaller study of CRP, using the same method and published last October in The New England Journal of Medicine, came to the same conclusion. But this second, larger, study was needed to convince heart experts, said Dr. Sekar Kathiresan, director of preventive cardiology at Massachusetts General Hospital.

Dr. Rader tests CRP to help decide whether to give a statin to patients with normal cholesterol but with a family history of heart disease. A high CRP, he said, could tip the balance, leading him to prescribe a statin. Dr. Altshuler noted that part of the power of a Mendelian randomization study was that it could stop a hypothesis from prematurely becoming viewed as fact.

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true. And if the clinical trial contradicts the hypothesis, people are unwilling to question their beliefs, even if there was no evidence of causality to begin with, Dr. .

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Dr. Rader, at Penn, said he still did CRP Adidas Superstar Womens Tumblr tests on selected patients and expected to continue. An elevated CRP level indicates increased risk, even if the protein does not cause the risk. Adidas Superstar Suede Womens

Ordinarily, science starts with an observation, like the one associating CRP with heart disease. That generates a hypothesis that CRP causes heart disease. Then comes a trial, if there is a treatment, like a drug to specifically attack CRP, that people can be randomly chosen to take or not. But it can be years or decades before the clinical trials are completed. In the meantime, Dr. Altshuler said, the hypothesis Adidas Superstar Shoes Australia

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